Welcome to the site of the van Noort group. In our biophysics group we focus on chromatin. Chromatin is the ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms. Packaging and depackaging of such chromatin, called chromatin remodelling, plays a central role in all cellular processes that involve chromosomes such as transcription, replication, recombination, repair etc. Detailed knowledge of the principles and mechanisms underlying this control of DNA condensation is thus vital for understanding many diseases, including cancer. Eukaryotic cells have two major pathways to control DNA condensation. First, a large and very diverse group of enzymes has been found to chemically modify histone tails. Some of these covalent modifications, like acetylation, have been shown to modulate packaging of DNA. Alternatively, histone modifications may act as a docking site for additional chromatin processing enzymes. Second, ATP-dependent remodellers have been identified and are thought to move over DNA, and while doing so release DNA from histones. The physical mechanisms governing these processes however, are still largely unknown. In our group we develop and use modern biophysical techniques to unravel the physics behind DNA condensation.